House of Leaves was accompanied by a companion piece (or vice versa), a full-length album called Haunted recorded by Danielewski's sister, Anne Danielewski, known professionally as Poe. 

The two works cross-pollinated heavily over the course of their creations, each inspiring the other in various ways. Poe's statement on the connection between the two works is that they are parallax views of the same story. House of Leaves references Poe and her songs several times, not only limited to her album Haunted, but Hello as well. 

One example occurs when the character Karen Green is interviewing various academics on their interpretations of the short film "Exploration #4"; she consults a "Poet," but there is a space between the "Poe" and the "t," suggesting that Poe at one point commented on the book. It may also be a reference to Edgar Allan Poe.

The album Haunted also draws heavily from the novel, featuring tracks called "House of Leaves", "Exploration B" and "5&½ Minute Hallway", and many less obvious references. The video for "Hey Pretty" also features Mark Danielewski reading from House of Leaves (pp. 88–89), and in House of Leaves, the band Liberty Bell's lyrics were also songs on Poe's album.